Generally it works until you hit web browsers and flash – the i386 version of firefox works. 64bit has a gtk issue, pepper flash is not cross compiled with i386 so pepper won’t work, so your back to the old i386 flash.
I installed an esr version of firefox and that did work but i cant diagnose if its pure 64bit or both – it did moan about about missing 64bit flash – i think you know but i am past caring about it.
I am happy i dont use flash, since most of this is down to laziness on not cross compiling (google) and the copyright mafia who see things in a perverse way like using a youtube game clip and then dcma-ing it and will make a nightmare for there partners after all it probably is enforced on broadcasters that they must use this flash crap.
So i am using an i386 port of firefox, with a i386 flash on a amd64 machine, since pepper flash is apparently 64bit only which means the 64bit firefox version cannot access. If your head hurts sorry.
Well done everybody for fucking up video to get into this situation that affects more than just the linux os.